Accidental deletion of the description of the ME2HEADMORPH from the Windows registry.Incorrect links to the ME2HEADMORPH file in registry entries.Corruption of a ME2HEADMORPH file which is being opened.There may be other problems that also block our ability to operate the Mass Effect 2 Head Morph file. The inability to open and operate the ME2HEADMORPH file does not necessarily mean that you do not have an appropriate software installed on your computer. Possible problems with the ME2HEADMORPH format files